解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Anti-CD19 chimeric antigen receptor T cell (CAR-T) therapy has changed the typical outcomes of relapsed/refractory B-cell leukemia and lymphoma. However, treatment effectiveness for patients with relapsed/refractory B-cell non-Hodgkin lymphoma has been less satisfactory compared with patients with B-cell acute lymphob...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10783
更新日期:2019-11-01 00:00:00
abstract::Treatment of cancer often requires the use of adjuvant chemotherapy (ACT). In real clinical practice, numerous patients suffer from severe toxicity and reduced quality of life (QoL). Hence, there is a need to maintain QoL and to reduce therapy toxicity to comply with recommended chemotherapy (CT) regimens. The present...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10868
更新日期:2019-11-01 00:00:00
abstract::Linked color imaging (LCI) is a novel endoscopic system used to increase color contrast. As LCI does not decrease luminal brightness, it may improve the detection of colonic neoplasms. However, the extent to which LCI improves the visibility of colonic polyps has not yet been determined. Between December 2016 and May ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10917
更新日期:2019-11-01 00:00:00
abstract::Impairment of microRNA (miRNA) biogenesis may be involved in clear cell renal cell carcinoma (ccRCC). The objective of the present study was to investigate the mRNA levels of important miRNA machinery components, DICER1, DROSHA, DiGeroge syndrome critical region gene 8 (DGCR8), and Argonaute 2 (AGO2), and their correl...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10759
更新日期:2019-10-01 00:00:00
abstract::Carbohydrate sulfotransferase 15 (CHST15) synthesizes matrix proteoglycan that regulates various pathogenic mediators and contributes to tissue remodeling and fibrosis during injury. CHST15 has been reported to promote tumor growth and invasion in various types of cancer. Our previous study reported the safety and eff...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10764
更新日期:2019-10-01 00:00:00
abstract::Previous studies have demonstrated a significant difference in clinical characteristics between patients with non-small cell lung cancer (NSCLC) harboring exon 19 deletion (19-del) and an exon point mutation (21-L858R) in EGFR. The present retrospective study aimed to investigate the differential prognosis in patients...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10715
更新日期:2019-10-01 00:00:00
abstract::A previous study reported the decreased expression of long non-coding RNA mortal obligate RNA transcript (lncRNA MORT) in 16 types of cancer, while the functionality of lncRNA MORT in cancer biology remains unknown. Therefore, the present study was conducted to characterize the functionality of lncRNA MORT in prostate...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10711
更新日期:2019-10-01 00:00:00
abstract::N6-methyladenosine (m6A) is the most abundant eukaryote mRNA modification, modulated by regulators known as epigenetic writers, erasers and readers, which are known to serve crucial roles in mRNA metabolism. However, the role of m6A during B-cell development and B-cell tumorigenesis remains poorly understood. By analy...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10708
更新日期:2019-10-01 00:00:00
abstract::Ewing sarcoma (ES) is a highly malignant pediatric tumor with a low survival rate and a high rate of metastasis. However, there have been limited reports on the exploration of new biomarkers of ES. Therefore, the aim of the present study was to identify the potential hub genes associated with overall vital survival (O...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10681
更新日期:2019-10-01 00:00:00
abstract::Cervical cancer (CC) is one of the leading causes of cancer-associated mortalities in women from developing countries. Similar to other types of cancer, CC is considered to be a multifactorial disease, involving socioeconomic, cultural, immunological and epigenetic factors, as well as persistent human papilloma virus ...
journal_title:Oncology letters
pub_type: 杂志文章,评审
doi:10.3892/ol.2019.10718
更新日期:2019-10-01 00:00:00
abstract::Colorectal cancer (CRC) is the third leading cause of cancer-associated mortalities. Long non-coding RNAs (lncRNAs) have been identified as key regulators in the occurrence and development of CRC. The lncRNA urothelial cancer associated 1 (UCA1) has been demonstrated to promote the development of numerous different ty...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10737
更新日期:2019-10-01 00:00:00
abstract::Lung cancer negatively impacts global health, and the incidence of non-small cell lung cancer (NSCLC) is highest among all forms of lung cancer. Chemotherapy failure mainly occurs due to drug resistance; however, the associated molecular mechanism remains unclear. Casein kinase II (CK2), which plays important roles in...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10696
更新日期:2019-10-01 00:00:00
abstract::The correlation between expression and prognosis of thyroid transcription factor-1 (TTF-1) and CD44v6 in undifferentiated lung carcinoma was investigated. There were 116 cases with large cell undifferentiated carcinoma in group A, 120 cases with small cell undifferentiated carcinoma in group B and 80 normal individual...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10689
更新日期:2019-10-01 00:00:00
abstract::This study aimed to determine whether manipulation of the microRNA-200 (miR-200) family could influence colon adenocarcinoma cell behavior. The miR-200 family has a significant role in tumor suppression and functions as an oncogene. In vitro studies on gain and loss of function with small interfering RNA demonstrated ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10753
更新日期:2019-10-01 00:00:00
abstract::Cervical cancer pathogenesis is regulated by numerous factors, including microRNAs. MicroRNA 1246 (miR-1246) has been shown to serve a role in cervical cancer tumorigenesis. However, the mechanisms through which miR-1246 exerts its oncogenic effects are largely unknown. The aim of the current study was to evaluate the...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10571
更新日期:2019-09-01 00:00:00
abstract::Chronic myelogenous leukemia (CML) is a common hematological malignancy. Some patients progressing to the blast phase develop chemotherapeutic drug resistance. In the authors' previous study, it was found that the mammalian target of rapamycin (mTOR) pathway was activated in CML and that rapamycin inhibited the prolif...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10589
更新日期:2019-09-01 00:00:00
abstract::Expression level of miR-181c in neuroblastoma children and its effect on proliferation of neuroblastoma M17 cells were investigated. Fifty-seven neuroblastoma patients admitted to Weifang People's Hospital from January 2013 to December 2017 were selected and their cancer tissues and normal adjacent tissues were obtain...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10602
更新日期:2019-09-01 00:00:00
abstract::In order to assess the metastatic potential of residual hepatocellular carcinoma (HCC) following insufficient radiofrequency ablation (RFA) and to improve the current animal model, an insufficient RFA orthotopic nude mouse model of HCC was developed in the present study. A human HCC orthotopic nude mouse model was est...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10552
更新日期:2019-09-01 00:00:00
abstract::Septin 2 (SEPT2) is a tumor-related gene belonging to the SEPT family that affects the cellular processes of hepatoma carcinoma cells, glioblastoma cells and mesangial cells and is highly expressed in breast cancer, biliary tract cancer and acute myeloid leukemia. Colorectal cancer (CRC) is the third most common type ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10528
更新日期:2019-09-01 00:00:00
abstract::Discovering the underlying signalling pathways that control cancer cells is crucial for understanding their biology and to develop therapeutic regimens. Thus, the aim of the present study was to determine the effect of Cripto-1 on pathways controlling glioblastoma (GBM) cell function. To this end, changes in protein p...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10626
更新日期:2019-09-01 00:00:00
abstract::Tanshinone IIA exhibits natural antioxidative and antineoplastic activity. However, to the best of our knowledge, the effects of tanshinone IIA on human nasopharyngeal carcinoma cells remains unknown. The present study aimed to investigate whether tanshinone IIA inhibits proliferation and induces apoptosis of human na...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10658
更新日期:2019-09-01 00:00:00
abstract::In recent decades, thyroid cancer (TC) has become one of the most common endocrine malignancies. Next-generation sequencing of paired TC and adjacent healthy thyroid tissues demonstrated that polycystic kidney and hepatic disease 1-like 1 (PKHD1L1) may serve as a tumour suppressor gene in thyroid cancer. However, the ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10632
更新日期:2019-09-01 00:00:00
abstract::Acanthus ebracteatus Vahl. is commonly consumed with the aim of curing cancer, inflammatory conditions and skin diseases in traditional Thai medicine. It is known to contain various phytochemicals; however, very little is known about the effects of A. ebracteatus protein hydrolysate on cancer cells, including its mole...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10647
更新日期:2019-09-01 00:00:00
abstract::Lung cancer is one of the most common malignancies worldwide; however, its detailed molecular mechanism remains largely unknown. Long non-coding RNAs (lncRNAs) have been identified to serve critical roles in tumorigenesis. The aim of the present study was to investigate the role of a newly identified lncRNA, overexpre...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10644
更新日期:2019-09-01 00:00:00
abstract::Clinical evidence indicates that drug resistance is a major obstacle in the treatment of breast cancer (BC). Drug resistance results in the disease being uncontrollable, and leads to high mortality rates. The aim of the present study was to investigate the chemosensitizing effect of microRNA (miR)-16 on Adriamycin (AD...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10637
更新日期:2019-09-01 00:00:00
abstract::This study was designed to explore the expression of phosphoinositide-dependent protein kinase 1 (PDK-1), deleted in malignant brain tumors (DMBT1) in the thyroid carcinoma. A total of 87 fresh samples of thyroid carcinoma from surgical resection in The Second People's Hospital of Lianyungang from June 2016 to March 2...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10639
更新日期:2019-09-01 00:00:00
abstract::Nasopharyngeal carcinoma (NPC) is a common tumor in south China. Kinesin family member 2A (KIF2A) belongs to the kinesin-13 family and is associated with the growth and invasion of a number of different types of human cancer, including ovarian, breast and prostate cancer. The aim of the present study was to evaluate t...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10597
更新日期:2019-09-01 00:00:00
abstract::Osteosarcoma (OS) mortality rate is increasing. Various microRNAs (miRNAs) have been investigated in the pathological process of OS except for miR-744. Hence, this research was designed to explore miR-744 function in OS. RT-qPCR and western blot analysis were used to quantify miR-744 and large tumor suppressor kinase ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10530
更新日期:2019-09-01 00:00:00
abstract::Voltage-dependent anion channels (VDACs) are situated in the outer membrane of the mitochondria and serve as gatekeepers that control metabolite and ion exchange between the cytosol and mitochondria. VDAC1 is one of the most studied members of the VDAC protein family and is overexpressed in multiple types of cancer. H...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10534
更新日期:2019-09-01 00:00:00
abstract::Ovarian cancer (OVAC) remains the most lethal gynecological malignancy; it is ranked fifth among the most common types of cancer that affect women worldwide. Several aspects of the disease, including molecular pathogenesis, epidemiology, histological subtypes, poor prognosis at early stages due to the absence of speci...
journal_title:Oncology letters
pub_type: 杂志文章,评审
doi:10.3892/ol.2019.10587
更新日期:2019-09-01 00:00:00
abstract::LIM domain containing 2 (LIMD2) is a small LIM-only protein that has been demonstrated to promote tumor progression; however, the expression and function of LIMD2 in non-small cell lung cancer (NSCLC) has not previously been reported. In the present study, reverse transcription-quantitative PCR and western blot analys...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10473
更新日期:2019-08-01 00:00:00
abstract::Small cell lung cancer (SCLC) is a type of lung cancer characterized by a rapid disease progression and poor prognosis. Its diagnosis is often accompanied by distant metastasis. A literature review revealed that metastases to the stomach from breast, lung and esophageal cancer are frequently reported. While SCLC is a ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10484
更新日期:2019-08-01 00:00:00
abstract::Numerous studies have shown that marital status may be a prognostic factor in various malignancies, but little is known about its effect on duodenal adenocarcinoma. The aim of the present study was to determine the association between marital status and survival in patients with duodenal adenocarcinoma. The Surveillan...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10475
更新日期:2019-08-01 00:00:00
abstract::The aim of the present study was to establish a prediction index (PI) model for the 5-year survival rate of patients with hepatitis B-related hepatocellular carcinoma (HCC) after radical resection, and to evaluate the effect of prophylactic transcatheter arterial chemoembolization (TACE). A total of 201 patients with ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10517
更新日期:2019-08-01 00:00:00
abstract::The clinical effect of interventional therapy on gastric cancer after chemotherapy and effect on inflammatory factors in peripheral blood serum of patients were investigated. A retrospective analysis of 429 patients with gastric cancer treated in Xiangyang No. 1 People's Hospital, Hubei University of Medicine from Jul...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10505
更新日期:2019-08-01 00:00:00
abstract::Natural dietary components have become the subject of an increasing amount of interest due to the side effects of anticancer treatment. Pterostilbene, an analog of resveratrol, is primarily found in grapes, and has been suggested to exert antioxidant and anticancer effects in different tumor types. The present study a...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10499
更新日期:2019-08-01 00:00:00
abstract::The endogenous lipid metabolism network is associated with the occurrence and progression of malignancies. Endocannabinoids and ceramides have demonstrated their anti-proliferative and pro-apoptotic properties in a series of cancer studies. The aim of the present study was to evaluate the expression patterns of endoca...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10399
更新日期:2019-08-01 00:00:00
abstract::Patients with chronic inflammatory bowel disease have an increased risk of colorectal cancer, and the differentiation between neoplastic and inflammatory lesions often poses a clinical dilemma. The aim of the present study was to investigate whether diffusion-weighted (DW) magnetic resonance (MR) enterography with ult...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10441
更新日期:2019-08-01 00:00:00
abstract::Previous studies have revealed several genes involved in the carcinogenesis of oral cancer. However, the detailed mechanisms underlying this process are poorly understood. Previously, we established a database cataloging the transcriptional progression profile of oral carcinogenesis and identified several candidate ge...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10420
更新日期:2019-08-01 00:00:00
abstract::ATPase family AAA domain-containing protein 3 (ATAD3) is a mitochondrial membrane-bound ATPase that is involved in a number of cellular processes and is linked with the progression of various types of malignancies. In primates, the ATAD3 gene cluster contains ATAD3A, ATAD3B and ATAD3C. The association between ATAD3 ge...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10454
更新日期:2019-08-01 00:00:00